A new class of small molecule inhibitor of BMP signaling.

A new class of small molecule inhibitor of BMP signaling.

Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor kinase ALK2 (ACVR1) are needed urgently to treat the progressively debilitati...

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Main Authors: Caroline E Sanvitale, Georgina Kerr, Apirat Chaikuad, Marie-Christine Ramel, Agustin H Mohedas, Sabine Reichert, You Wang, James T Triffitt, Gregory D Cuny, Paul B Yu, Caroline S Hill, Alex N Bullock
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3639963?pdf=render

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