Role of CYP3A5 in Modulating Androgen Receptor Signaling and Its Relevance to African American Men with Prostate Cancer

Role of CYP3A5 in Modulating Androgen Receptor Signaling and Its Relevance to African American Men with Prostate Cancer

Androgen receptor signaling is crucial for prostate cancer growth and is positively regulated in part by intratumoral CYP3A5. As African American (AA) men often carry the wild type CYP3A5 and express high levels of CYP3A5 protein, we blocked the wild type CYP3A5 in AA origin prostate cancer cells an...

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Bibliographic Details
Main Authors: Priyatham Gorjala, Rick A. Kittles, Oscar B. Goodman, Ranjana Mitra
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
CYP3A5
androgen receptor
African American
CYP3A5 inhibitors/inducers
Online Access:https://www.mdpi.com/2072-6694/12/4/989

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