A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8

A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8

Retinitis pigmentosa (RP) represents genetically heterogeneous and clinically variable disease characterized by progressive degeneration of photoreceptors resulting in a gradual loss of vision. The autosomal dominant RP type 13 (RP13) has been linked to the malfunction of PRPF8, an essential compone...

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Bibliographic Details
Main Authors: Dimitrije Stanković, Ann-Katrin Claudius, Thomas Schertel, Tina Bresser, Mirka Uhlirova
Format: Article
Language:English
Published: The Company of Biologists 2020-06-01
Series:Disease Models & Mechanisms
Subjects:
drosophila
prp8
retinitis pigmentosa
apoptosis
eye development
splicing factor
Online Access:http://dmm.biologists.org/content/13/6/dmm043174

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