Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury

Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury

Abstract Background Despite the fact that histone deacetylase (HDAC) inhibitors have been tested to treat various cardiovascular diseases, the effects of selective HDAC6 inhibitor ACY1215 on infarct size during cardiac ischemia-reperfusion (IR) injury still remain unknown. In the present study we ai...

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Bibliographic Details
Main Authors: Chao-Feng Lin, Kai-Cheng Hsu, Wei-Chun HuangFu, Tony Eight Lin, Han-Li Huang, Shiow-Lin Pan
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Pharmacology and Toxicology
Subjects:
Myocardial infarction
Ischemia-reperfusion injury
Histone deacetylase 6 inhibitor
Hypoxia inducible factor-1α
Infarct size
Online Access:http://link.springer.com/article/10.1186/s40360-020-0400-0

Internet

http://link.springer.com/article/10.1186/s40360-020-0400-0

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