Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington’s Disease

Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington’s Disease

Poly (ADP-ribose) polymerases (PARPs) are enzymes that catalyze ADP-ribose units transfer from NAD to their substrate proteins. It has been observed that PARP-1 is able to increase both post-ischemic and excitotoxic neuronal death. In fact, we have previously shown that, INO-1001, a PARP-1 inhibitor...

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Bibliographic Details
Main Authors: Emanuela Paldino, Antonella Cardinale, Vincenza D’Angelo, Ilaria Sauve, Carmela Giampà, Francesca R. Fusco
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neuroanatomy
Subjects:
Huntington’s disease
neurodegeneration
PARP-1 inhibition
CBP
pCREB
interneurons
Online Access:http://journal.frontiersin.org/article/10.3389/fnana.2017.00061/full

Internet

http://journal.frontiersin.org/article/10.3389/fnana.2017.00061/full

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