Calcium Deregulation: Novel Insights to Understand Friedreich’s Ataxia Pathophysiology

Calcium Deregulation: Novel Insights to Understand Friedreich’s Ataxia Pathophysiology

Friedreich’s Ataxia (FRDA) is a neurodegenerative disorder, characterized by degeneration of dorsal root ganglia, cerebellum and cardiomyopathy. Heart failure is one of the most common causes of death for FRDA patients. Deficiency of frataxin, a small mitochondrial protein, is responsible for all cl...

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Bibliographic Details
Main Authors: Rosella Abeti, Alexander F. Brown, Marta Maiolino, Sandip Patel, Paola Giunti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
FRDA
CGNs
cardiomyocytes
calcium
oxidative stress
sarcoplasmic reticulum
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00264/full

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