Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System

Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System

A new series of tetrahydrocarbazole coupled 1,2-diazoles 4/5/6(a–o) in moderate to excellent yield was synthesized successfully via multicomponent reaction approach by adopting Michael type-addition of hydrazines on in situ generated α,β-unsaturated ketones via aldol type strategy under synthetic mi...

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Main Authors: Zubi Sadiq, Erum Akbar Hussain, Narjis Naz, Ambreen Ghani, Kausar Yasmeen, Fizzah Iqbal
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2017/3902751
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spelling doaj-4f0bb03d1ed94efd9b94cb3c0296bc8d2020-11-24T23:40:00ZengHindawi LimitedJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/39027513902751Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic SystemZubi Sadiq0Erum Akbar Hussain1Narjis Naz2Ambreen Ghani3Kausar Yasmeen4Fizzah Iqbal5Department of Chemistry, Lahore College for Women University, Lahore 54000, PakistanDepartment of Chemistry, Lahore College for Women University, Lahore 54000, PakistanDepartment of Chemistry, Lahore College for Women University, Lahore 54000, PakistanDepartment of Chemistry, University of Education, D.G. Khan Campus, Dera Ghazi Khan, PakistanDepartment of Chemistry, Lahore College for Women University, Lahore 54000, PakistanDepartment of Chemistry, Lahore College for Women University, Lahore 54000, PakistanA new series of tetrahydrocarbazole coupled 1,2-diazoles 4/5/6(a–o) in moderate to excellent yield was synthesized successfully via multicomponent reaction approach by adopting Michael type-addition of hydrazines on in situ generated α,β-unsaturated ketones via aldol type strategy under synthetic microwave radiations and conventional heating. Structural confirmations of all the prepared compounds were achieved by spectroscopic techniques. The best results were achieved when equal amounts of water-acetic acid were used in microwave conditions in 4 minutes.http://dx.doi.org/10.1155/2017/3902751
collection DOAJ
language English
format Article
sources DOAJ
author Zubi Sadiq
Erum Akbar Hussain
Narjis Naz
Ambreen Ghani
Kausar Yasmeen
Fizzah Iqbal
spellingShingle Zubi Sadiq
Erum Akbar Hussain
Narjis Naz
Ambreen Ghani
Kausar Yasmeen
Fizzah Iqbal
Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System
Journal of Chemistry
author_facet Zubi Sadiq
Erum Akbar Hussain
Narjis Naz
Ambreen Ghani
Kausar Yasmeen
Fizzah Iqbal
author_sort Zubi Sadiq
title Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System
title_short Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System
title_full Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System
title_fullStr Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System
title_full_unstemmed Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System
title_sort microwave-assisted synthesis of tetrahydrocarbazole linked 1,2-diazoles in aqueous-brønsted acid catalytic system
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2017-01-01
description A new series of tetrahydrocarbazole coupled 1,2-diazoles 4/5/6(a–o) in moderate to excellent yield was synthesized successfully via multicomponent reaction approach by adopting Michael type-addition of hydrazines on in situ generated α,β-unsaturated ketones via aldol type strategy under synthetic microwave radiations and conventional heating. Structural confirmations of all the prepared compounds were achieved by spectroscopic techniques. The best results were achieved when equal amounts of water-acetic acid were used in microwave conditions in 4 minutes.
url http://dx.doi.org/10.1155/2017/3902751
work_keys_str_mv AT zubisadiq microwaveassistedsynthesisoftetrahydrocarbazolelinked12diazolesinaqueousbrønstedacidcatalyticsystem
AT erumakbarhussain microwaveassistedsynthesisoftetrahydrocarbazolelinked12diazolesinaqueousbrønstedacidcatalyticsystem
AT narjisnaz microwaveassistedsynthesisoftetrahydrocarbazolelinked12diazolesinaqueousbrønstedacidcatalyticsystem
AT ambreenghani microwaveassistedsynthesisoftetrahydrocarbazolelinked12diazolesinaqueousbrønstedacidcatalyticsystem
AT kausaryasmeen microwaveassistedsynthesisoftetrahydrocarbazolelinked12diazolesinaqueousbrønstedacidcatalyticsystem
AT fizzahiqbal microwaveassistedsynthesisoftetrahydrocarbazolelinked12diazolesinaqueousbrønstedacidcatalyticsystem
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