Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation

Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation

Toward further implementation of continuous tablet manufacturing, one key issue is the time needed for start-up operation because it could lead to lower product yield and reduced economic performance. The behavior of the start-up operation is not well understood; moreover, the definition of the star...

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Bibliographic Details
Main Authors: Kensaku Matsunami, Alexander Ryckaert, Michiel Peeters, Sara Badr, Hirokazu Sugiyama, Ingmar Nopens, Thomas De Beer
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Processes
Subjects:
continuous manufacturing
pharmaceutical tablet
design of experiments
torque
granule size distribution
first-order system
Online Access:https://www.mdpi.com/2227-9717/9/9/1502

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