Donepezil Ameliorates Pulmonary Arterial Hypertension by Inhibiting M2-Macrophage Activation

Donepezil Ameliorates Pulmonary Arterial Hypertension by Inhibiting M2-Macrophage Activation

Background: The beneficial effects of parasympathetic stimulation in pulmonary arterial hypertension (PAH) have been reported. However, the specific mechanism has not been completely clarified. Donepezil, an oral cholinesterase inhibitor, enhances parasympathetic activity by inhibiting acetylcholine...

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Bibliographic Details
Main Authors:	Haihua Qiu, Yibo Zhang, Zhongyu Li, Ping Jiang, Shuhong Guo, Yi He, Yuan Guo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	donepezil pulmonary arterial hypertension cholinesterase inhibitor M2-macrophage pulmonary arterial smooth muscle cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2021.639541/full

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