Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of <i>Stratum basale</i> Keratinocytes

Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of <i>Stratum basale</i> Keratinocytes

Melanin granules cluster within supra-nuclear caps in basal keratinocytes (KCs) of the human epidermis, where they protect KC genomic DNA against ultraviolet radiation (UVR) damage. While much is known about melanogenesis in melanocytes (MCs) and a moderate amount about melanin transfer from MC to K...

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Bibliographic Details
Main Authors: Irene Castellano-Pellicena, Ciaran G. Morrison, Mike Bell, Clare O’Connor, Desmond J. Tobin
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
melanin distribution
epidermis
<i>Stratum basale</i> keratinocytes
ex vivo human skin
skin phototype
centrosome
Online Access:https://www.mdpi.com/1422-0067/22/6/3143

Internet

https://www.mdpi.com/1422-0067/22/6/3143

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