Alternate subunit assembly diversifies the function of a bacterial toxin

Alternate subunit assembly diversifies the function of a bacterial toxin

Salmonella Typhi produces the typhoid toxin. Here, Fowler et al. show that S. Typhi produces two forms of typhoid toxin that are differentially regulated and display different trafficking properties and different effects when administered to laboratory animals.

Bibliographic Details
Main Authors: Casey C. Fowler, Gabrielle Stack, Xuyao Jiao, Maria Lara-Tejero, Jorge E. Galán
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11592-0
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spelling doaj-4ef4c66184da419daeb906136af365182021-05-11T12:38:04ZengNature Publishing GroupNature Communications2041-17232019-08-0110111010.1038/s41467-019-11592-0Alternate subunit assembly diversifies the function of a bacterial toxinCasey C. Fowler0Gabrielle Stack1Xuyao Jiao2Maria Lara-Tejero3Jorge E. Galán4Department of Microbial Pathogenesis, Yale University School of MedicineDepartment of Microbial Pathogenesis, Yale University School of MedicineDepartment of Microbial Pathogenesis, Yale University School of MedicineDepartment of Microbial Pathogenesis, Yale University School of MedicineDepartment of Microbial Pathogenesis, Yale University School of MedicineSalmonella Typhi produces the typhoid toxin. Here, Fowler et al. show that S. Typhi produces two forms of typhoid toxin that are differentially regulated and display different trafficking properties and different effects when administered to laboratory animals.https://doi.org/10.1038/s41467-019-11592-0
collection DOAJ
language English
format Article
sources DOAJ
author Casey C. Fowler
Gabrielle Stack
Xuyao Jiao
Maria Lara-Tejero
Jorge E. Galán
spellingShingle Casey C. Fowler
Gabrielle Stack
Xuyao Jiao
Maria Lara-Tejero
Jorge E. Galán
Alternate subunit assembly diversifies the function of a bacterial toxin
Nature Communications
author_facet Casey C. Fowler
Gabrielle Stack
Xuyao Jiao
Maria Lara-Tejero
Jorge E. Galán
author_sort Casey C. Fowler
title Alternate subunit assembly diversifies the function of a bacterial toxin
title_short Alternate subunit assembly diversifies the function of a bacterial toxin
title_full Alternate subunit assembly diversifies the function of a bacterial toxin
title_fullStr Alternate subunit assembly diversifies the function of a bacterial toxin
title_full_unstemmed Alternate subunit assembly diversifies the function of a bacterial toxin
title_sort alternate subunit assembly diversifies the function of a bacterial toxin
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description Salmonella Typhi produces the typhoid toxin. Here, Fowler et al. show that S. Typhi produces two forms of typhoid toxin that are differentially regulated and display different trafficking properties and different effects when administered to laboratory animals.
url https://doi.org/10.1038/s41467-019-11592-0
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AT gabriellestack alternatesubunitassemblydiversifiesthefunctionofabacterialtoxin
AT xuyaojiao alternatesubunitassemblydiversifiesthefunctionofabacterialtoxin
AT marialaratejero alternatesubunitassemblydiversifiesthefunctionofabacterialtoxin
AT jorgeegalan alternatesubunitassemblydiversifiesthefunctionofabacterialtoxin
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