Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins

Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins

Viral protein R (Vpr) is an accessory protein found in various primate lentiviruses, including human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) as well as simian immunodeficiency viruses (SIVs). Vpr modulates many processes during viral lifecycle via interaction with several of cellular...

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Bibliographic Details
Main Authors: Hao Chang, Lowela Siarot, Ryosuke Matsuura, Chieh-Wen Lo, Hirotaka Sato, Hiroyuki Otsuki, Yoko Aida
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Viruses
Subjects:
primate lentiviruses
vpr
mcm10
proteasomal degradation
dna damage response
g<sub>2</sub>/m arrest
Online Access:https://www.mdpi.com/1999-4915/12/1/98

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