Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates

The diversity of primary sensory neurons and how fate choice is determined is unclear. Here, the authors use single cell RNA sequencing analysis of early murine somatosensory neurons to show that sensory neuron diversity is achieved by a transition through a bi-potential intermediate state.

Bibliographic Details
Main Authors: Louis Faure, Yiqiao Wang, Maria Eleni Kastriti, Paula Fontanet, Kylie K. Y. Cheung, Charles Petitpré, Haohao Wu, Lynn Linyu Sun, Karen Runge, Laura Croci, Mark A. Landy, Helen C. Lai, Gian Giacomo Consalez, Antoine de Chevigny, François Lallemend, Igor Adameyko, Saida Hadjab
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17929-4
Description
Summary:The diversity of primary sensory neurons and how fate choice is determined is unclear. Here, the authors use single cell RNA sequencing analysis of early murine somatosensory neurons to show that sensory neuron diversity is achieved by a transition through a bi-potential intermediate state.
ISSN:2041-1723