Discovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing Fluostatins

Discovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing Fluostatins

Diazobenzofluorene-containing atypical angucyclines exhibit promising biological activities. Here we report the inactivation of an amidotransferase-encoding gene flsN3 in Micromonospora rosaria SCSIO N160, a producer of fluostatins. Bioinformatics analysis indicated that FlsN3 was involved in the di...

Full description

Bibliographic Details
Main Authors: Chunshuai Huang, Chunfang Yang, Zhuangjie Fang, Liping Zhang, Wenjun Zhang, Yiguang Zhu, Changsheng Zhang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Marine Drugs
Subjects:
angucyclines
N–N bond
raceme
gene inactivation
biosynthesis
marine
Micromonospora
Online Access:http://www.mdpi.com/1660-3397/17/3/150

Internet

http://www.mdpi.com/1660-3397/17/3/150

Similar Items