Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.

Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.

CUG-BP and ETR-3-like factor (CELF) proteins regulate tissue- and developmental stage-specific alternative splicing in striated muscle. We previously demonstrated that heart muscle-specific expression of a nuclear dominant negative CELF protein in transgenic mice (MHC-CELFΔ) effectively disrupts end...

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Bibliographic Details
Main Authors: Dara S Berger, Michelle Moyer, Gregory M Kliment, Erik van Lunteren, Andrea N Ladd
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3082560?pdf=render

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http://europepmc.org/articles/PMC3082560?pdf=render

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