Durable Progression-Free Survival With the Use of BRAF and MEK Inhibitors in Four Cases With V600E-Mutated Gliomas

Durable Progression-Free Survival With the Use of BRAF and MEK Inhibitors in Four Cases With V600E-Mutated Gliomas

Introduction BRAF V600 E mutations have been identified in a subset of patients with primary brain tumors. Combination therapy with BRAF and Mitogen-activated protein kinase (MEK) inhibitors (BRAF/MEKi) targeting sequential steps in the MAPK pathway has replaced BRAFi monotherapy as the standard of...

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Bibliographic Details
Main Authors:	Michael J. Fusco PharmD, Yolanda Piña MD, Robert J. Macaulay MD, Solmaz Sahebjam MD, Peter A. Forsyth MD, Edwin Peguero MD, Christine M. Walko PharmD
Format:	Article
Language:	English
Published:	SAGE Publishing 2021-09-01
Series:	Cancer Control
Online Access:	https://doi.org/10.1177/10732748211040013

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