The pharmacological and clinical aspects behind dose loading of biological disease modifying anti-rheumatic drugs (bDMARDs) in auto-immune rheumatic diseases (AIRDs): rationale and systematic narrative review of clinical evidence

The pharmacological and clinical aspects behind dose loading of biological disease modifying anti-rheumatic drugs (bDMARDs) in auto-immune rheumatic diseases (AIRDs): rationale and systematic narrative review of clinical evidence

Abstract Background Dose loading of biological disease modifying anti-rheumatic drugs (bDMARDs) in auto-immune rheumatic diseases (AIRDs) is performed to achieve steady state drug concentrations earlier after treatment start compared to dosing regimens without loading. Although loading inherently re...

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Bibliographic Details
Main Authors: Gerlienke E. Geurts-Voerman, Lise M. Verhoef, Bart J. F. van den Bemt, Alfons A. den Broeder
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Rheumatology
Subjects:
Auto-immune rheumatic disease (AIRD)
Biological DMARD
Dose loading
Pharmacodynamics / pharmacokinetics
Pharmaco-economics
Online Access:http://link.springer.com/article/10.1186/s41927-020-00130-x

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http://link.springer.com/article/10.1186/s41927-020-00130-x

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