A mathematical model for electrical stimulation of a monolayer of cardiac cells

A mathematical model for electrical stimulation of a monolayer of cardiac cells

<p>Abstract</p> <p>Background</p> <p>The goal of our study is to examine the effect of stimulating a two-dimensional sheet of myocardial cells. We assume that the stimulating electrode is located in a bath perfusing the tissue.</p> <p>Methods</p> <p...

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Main Authors: Roth Bradley J, Srinivasan Ranjini
Format: Article
Language:English
Published: BMC 2004-01-01
Series:BioMedical Engineering OnLine
Online Access:http://www.biomedical-engineering-online.com/content/3/1/1
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spelling doaj-4ed63cbc098141b7954f3e0a3453fa892020-11-24T22:19:34ZengBMCBioMedical Engineering OnLine1475-925X2004-01-0131110.1186/1475-925X-3-1A mathematical model for electrical stimulation of a monolayer of cardiac cellsRoth Bradley JSrinivasan Ranjini<p>Abstract</p> <p>Background</p> <p>The goal of our study is to examine the effect of stimulating a two-dimensional sheet of myocardial cells. We assume that the stimulating electrode is located in a bath perfusing the tissue.</p> <p>Methods</p> <p>An equation governing the transmembrane potential, based on the continuity equation and Ohm's law, is solved numerically using a finite difference technique.</p> <p>Results</p> <p>The sheet is depolarized under the stimulating electrode and is hyperpolarized on each side of the electrode along the fiber axis.</p> <p>Conclusions</p> <p>The results are similar to those obtained previously by Sepulveda et al. (Biophys J, 55: 987–999, 1989) for stimulation of a two-dimensional sheet of tissue with no perfusing bath present.</p> http://www.biomedical-engineering-online.com/content/3/1/1
collection DOAJ
language English
format Article
sources DOAJ
author Roth Bradley J
Srinivasan Ranjini
spellingShingle Roth Bradley J
Srinivasan Ranjini
A mathematical model for electrical stimulation of a monolayer of cardiac cells
BioMedical Engineering OnLine
author_facet Roth Bradley J
Srinivasan Ranjini
author_sort Roth Bradley J
title A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_short A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_full A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_fullStr A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_full_unstemmed A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_sort mathematical model for electrical stimulation of a monolayer of cardiac cells
publisher BMC
series BioMedical Engineering OnLine
issn 1475-925X
publishDate 2004-01-01
description <p>Abstract</p> <p>Background</p> <p>The goal of our study is to examine the effect of stimulating a two-dimensional sheet of myocardial cells. We assume that the stimulating electrode is located in a bath perfusing the tissue.</p> <p>Methods</p> <p>An equation governing the transmembrane potential, based on the continuity equation and Ohm's law, is solved numerically using a finite difference technique.</p> <p>Results</p> <p>The sheet is depolarized under the stimulating electrode and is hyperpolarized on each side of the electrode along the fiber axis.</p> <p>Conclusions</p> <p>The results are similar to those obtained previously by Sepulveda et al. (Biophys J, 55: 987–999, 1989) for stimulation of a two-dimensional sheet of tissue with no perfusing bath present.</p>
url http://www.biomedical-engineering-online.com/content/3/1/1
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AT srinivasanranjini amathematicalmodelforelectricalstimulationofamonolayerofcardiaccells
AT rothbradleyj mathematicalmodelforelectricalstimulationofamonolayerofcardiaccells
AT srinivasanranjini mathematicalmodelforelectricalstimulationofamonolayerofcardiaccells
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