| Summary: | <p>Abstract</p> <p>Background</p> <p>The goal of our study is to examine the effect of stimulating a two-dimensional sheet of myocardial cells. We assume that the stimulating electrode is located in a bath perfusing the tissue.</p> <p>Methods</p> <p>An equation governing the transmembrane potential, based on the continuity equation and Ohm's law, is solved numerically using a finite difference technique.</p> <p>Results</p> <p>The sheet is depolarized under the stimulating electrode and is hyperpolarized on each side of the electrode along the fiber axis.</p> <p>Conclusions</p> <p>The results are similar to those obtained previously by Sepulveda et al. (Biophys J, 55: 987–999, 1989) for stimulation of a two-dimensional sheet of tissue with no perfusing bath present.</p>
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