Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.
One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basi...
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MDPI AG
2012-04-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/10/5/987/ |
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doaj-4ec97b80c7d64411b6f2f39ad895a4fc2020-11-25T01:19:31ZengMDPI AGMarine Drugs1660-33972012-04-01105987997Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.Jui-Hsin SuMei-Chin LuYalan ChouYuan-Shing HoLi-Lian LiuYu-Chia ChangShang-Wei TsengOne new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3–5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines.http://www.mdpi.com/1660-3397/10/5/987/sesterterpenoidscalaranespongeHippospongia |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jui-Hsin Su Mei-Chin Lu Yalan Chou Yuan-Shing Ho Li-Lian Liu Yu-Chia Chang Shang-Wei Tseng |
| spellingShingle |
Jui-Hsin Su Mei-Chin Lu Yalan Chou Yuan-Shing Ho Li-Lian Liu Yu-Chia Chang Shang-Wei Tseng Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. Marine Drugs sesterterpenoid scalarane sponge Hippospongia |
| author_facet |
Jui-Hsin Su Mei-Chin Lu Yalan Chou Yuan-Shing Ho Li-Lian Liu Yu-Chia Chang Shang-Wei Tseng |
| author_sort |
Jui-Hsin Su |
| title |
Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_short |
Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_full |
Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_fullStr |
Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_full_unstemmed |
Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_sort |
cytotoxic sesterterpenoids from a sponge hippospongia sp. |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2012-04-01 |
| description |
One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3–5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines. |
| topic |
sesterterpenoid scalarane sponge Hippospongia |
| url |
http://www.mdpi.com/1660-3397/10/5/987/ |
| work_keys_str_mv |
AT juihsinsu cytotoxicsesterterpenoidsfromaspongehippospongiasp AT meichinlu cytotoxicsesterterpenoidsfromaspongehippospongiasp AT yalanchou cytotoxicsesterterpenoidsfromaspongehippospongiasp AT yuanshingho cytotoxicsesterterpenoidsfromaspongehippospongiasp AT lilianliu cytotoxicsesterterpenoidsfromaspongehippospongiasp AT yuchiachang cytotoxicsesterterpenoidsfromaspongehippospongiasp AT shangweitseng cytotoxicsesterterpenoidsfromaspongehippospongiasp |
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1725137808231759872 |