Chemoprevention of oral cancer

Oral cancer is one among the ten most common cancers in the world and shows a marked geographic variation in occurrence. It causes considerable morbidity and is associated with a 5-year survival rate of less than 50%. Current treatment primarily consists of surgery and radiotherapy and improvement i...

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Main Authors: Yogesh Chhaparwal, Keerthilatha Pai, R Vineetha
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2012-01-01
Series:Journal of Indian Academy of Oral Medicine and Radiology
Subjects:
Online Access:http://www.jiaomr.in/article.asp?issn=0972-1363;year=2012;volume=24;issue=1;spage=39;epage=44;aulast=Chhaparwal
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spelling doaj-4ec1f50b66594e9886cbebcdd5bb530c2020-11-24T22:42:52ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13630975-15722012-01-012413944Chemoprevention of oral cancerYogesh ChhaparwalKeerthilatha PaiR VineethaOral cancer is one among the ten most common cancers in the world and shows a marked geographic variation in occurrence. It causes considerable morbidity and is associated with a 5-year survival rate of less than 50%. Current treatment primarily consists of surgery and radiotherapy and improvement in long-term cure rates with these modalities has reached a plateau. As, curative therapy available for oral cancer often results in debilitating changes in appearance, speech, swallowing and breathing, preventive strategies are desirable. Cancer chemoprevention is the use of natural, synthetic or biologic chemical agents to reverse, suppress, or prevent carcinogenic progression. Chemoprevention has been an extensively-studied strategy and continues to hold promise in the management of oral cancer. Many agents have been evaluated as possible chemopreventive agents including vitamin A and retinoids, betacarotene, vitamin E and dietary agents. Recently, molecularly targeted approach has generated interest among researchers worldwide which includes cyclooxygenase-2 (COX-2) inhibitors, EGFR inhibitors and adenovirus vectors. This article reviews the various aspects of chemoprevention and describes important chemopreventive agents and design of chemopreventive trials.http://www.jiaomr.in/article.asp?issn=0972-1363;year=2012;volume=24;issue=1;spage=39;epage=44;aulast=ChhaparwalOral cancerChemopreventionAntioxidants
collection DOAJ
language English
format Article
sources DOAJ
author Yogesh Chhaparwal
Keerthilatha Pai
R Vineetha
spellingShingle Yogesh Chhaparwal
Keerthilatha Pai
R Vineetha
Chemoprevention of oral cancer
Journal of Indian Academy of Oral Medicine and Radiology
Oral cancer
Chemoprevention
Antioxidants
author_facet Yogesh Chhaparwal
Keerthilatha Pai
R Vineetha
author_sort Yogesh Chhaparwal
title Chemoprevention of oral cancer
title_short Chemoprevention of oral cancer
title_full Chemoprevention of oral cancer
title_fullStr Chemoprevention of oral cancer
title_full_unstemmed Chemoprevention of oral cancer
title_sort chemoprevention of oral cancer
publisher Wolters Kluwer Medknow Publications
series Journal of Indian Academy of Oral Medicine and Radiology
issn 0972-1363
0975-1572
publishDate 2012-01-01
description Oral cancer is one among the ten most common cancers in the world and shows a marked geographic variation in occurrence. It causes considerable morbidity and is associated with a 5-year survival rate of less than 50%. Current treatment primarily consists of surgery and radiotherapy and improvement in long-term cure rates with these modalities has reached a plateau. As, curative therapy available for oral cancer often results in debilitating changes in appearance, speech, swallowing and breathing, preventive strategies are desirable. Cancer chemoprevention is the use of natural, synthetic or biologic chemical agents to reverse, suppress, or prevent carcinogenic progression. Chemoprevention has been an extensively-studied strategy and continues to hold promise in the management of oral cancer. Many agents have been evaluated as possible chemopreventive agents including vitamin A and retinoids, betacarotene, vitamin E and dietary agents. Recently, molecularly targeted approach has generated interest among researchers worldwide which includes cyclooxygenase-2 (COX-2) inhibitors, EGFR inhibitors and adenovirus vectors. This article reviews the various aspects of chemoprevention and describes important chemopreventive agents and design of chemopreventive trials.
topic Oral cancer
Chemoprevention
Antioxidants
url http://www.jiaomr.in/article.asp?issn=0972-1363;year=2012;volume=24;issue=1;spage=39;epage=44;aulast=Chhaparwal
work_keys_str_mv AT yogeshchhaparwal chemopreventionoforalcancer
AT keerthilathapai chemopreventionoforalcancer
AT rvineetha chemopreventionoforalcancer
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