Multifaceted Role of the Transforming Growth Factor β on Effector T Cells and the Implication for CAR-T Cell Therapy

Multifaceted Role of the Transforming Growth Factor β on Effector T Cells and the Implication for CAR-T Cell Therapy

Evading the immune system is one of the hallmarks of cancer. Tumors escape anti-tumor immunity through cell-intrinsic means and the assembly of an immunosuppressive tumor microenvironment. By significantly boosting the host immune system, cancer immunotherapies targeting immune checkpoint receptors...

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Bibliographic Details
Main Authors: Apolline de Folmont, Jean-Henri Bourhis, Salem Chouaib, Stéphane Terry
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Immuno
Subjects:
tumor microenvironment
TGF-beta
CAR-T
lymphocyte
immunotherapy
adoptive T-cell therapy
Online Access:https://www.mdpi.com/2673-5601/1/3/10

Internet

https://www.mdpi.com/2673-5601/1/3/10

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