Inherited and Acquired Decrease in Complement Receptor 1 (CR1) Density on Red Blood Cells Associated with High Levels of Soluble CR1 in Alzheimer’s Disease

Inherited and Acquired Decrease in Complement Receptor 1 (CR1) Density on Red Blood Cells Associated with High Levels of Soluble CR1 in Alzheimer’s Disease

The complement receptor 1 (CR1) gene was shown to be involved in Alzheimer’s disease (AD). We previously showed that AD is associated with low density of the long CR1 isoform, CR1*2 (S). Here, we correlated phenotype data (CR1 density per erythrocyte (CR1/E), blood soluble CR1 (sCR1)) with...

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Bibliographic Details
Main Authors: Rachid Mahmoudi, Sarah Feldman, Aymric Kisserli, Valérie Duret, Thierry Tabary, Laurie-Anne Bertholon, Sarah Badr, Vignon Nonnonhou, Aude Cesar, Antoine Neuraz, Jean Luc Novella, Jacques Henri Max Cohen
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
complement receptor 1
CR1 length polymorphism
CR1 density
complement C3b/C4b receptor
complement
dementia
molecular biology
neurosciences
genetic risk
Online Access:http://www.mdpi.com/1422-0067/19/8/2175

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