Partial Hypopituitarism Following Section Miscarriage: A Rare Presentation

• Main Authors: Monisha Priyadarshini Kumar, Nairmeen Haller, Daniela Ciltea
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2019-02-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: central hypothyroidism; pregnancy; selective hypopituitarism
• Online Access: https://jcdr.net/articles/PDF/12591/39815_CE[Ra1]_F(SHU)_PF1(AB_SL)_PN(SL).pdf

Hypopituitarism is a rare disorder with a prevalence of 45.5 cases per 100,000 individuals. The term “Selective or Partial Hypopituitarism” refers to the loss of at least one, but not all pituitary hormones. Gravid women are at high risk of developing hypopituitarism due to significant increase in the size of pituitary gland during pregnancy, and thus high propensity to undergo pituitary necrosis following hypotension from any source including labour, miscarriage or major blood loss. Although, it is an uncommon condition, early recognition and management play a crucial role in patient care. Here, a rare case of a 23-year-old Caucasian female who developed partial hypopituitarism, predominantly central hypothyroidism and minor gonadal hormonal deficiencies due to haemorrhage, during an episode of miscarriage is reported. She was managed medically with appropriate hormone replacement therapy with clinical improvement in symptoms.