Role and targeting of anaplastic lymphoma kinase in cancer

Role and targeting of anaplastic lymphoma kinase in cancer

Abstract Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and neuroblastoma, as a consequence of fusion with other oncogenes (NPM, EML4, TIM, et...

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Bibliographic Details
Main Authors: Carminia Maria Della Corte, Giuseppe Viscardi, Raimondo Di Liello, Morena Fasano, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello, Floriana Morgillo
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
ALK
Crizotinib
Alectinib
Ceritinib
Tyrosine kinase inhibitor
Resistance
Online Access:http://link.springer.com/article/10.1186/s12943-018-0776-2

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