Anti-Inflammatory Functions of Alverine via Targeting Src in the NF-κB Pathway

Anti-Inflammatory Functions of Alverine via Targeting Src in the NF-κB Pathway

Alverine, a smooth muscle relaxant, is used to relieve cramps or spasms of the stomach and intestine. Although the effects of alverine on spontaneous and induced contractile activity are well known, its anti-inflammatory activity has not been fully evaluated. In this study, we investigated the anti-...

Full description

Bibliographic Details
Main Authors:	Chae Young Lee, Han Gyung Kim, Sang Hee Park, Seok Gu Jang, Kyung Ja Park, Dong Sam Kim, Ji Hye Kim, Jae Youl Cho
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	Biomolecules
Subjects:	anti-inflammatory effect alverine Src inflammatory mediators NF-κB
Online Access:	https://www.mdpi.com/2218-273X/10/4/611

Similar Items

Single Dose Study Assessing the Pharmacokinetic and Metabolic Profile of Alverine Citrate in Healthy Volunteers
by: Simona Rizea-Savu, et al.
Published: (2021-01-01)

An improved LC-MS/MS method for the quantification of alverine and para hydroxy alverine in human plasma for a bioequivalence study☆
by: Dhiraj M. Rathod, et al.
Published: (2017-04-01)

<i>Ranunculus bulumei</i> Methanol Extract Exerts Anti-Inflammatory Activity by Targeting Src/Syk in NF-κB Signaling
by: Yo Han Hong, et al.
Published: (2020-04-01)

<i>Sorbaria kirilowii</i> Ethanol Extract Exerts Anti-Inflammatory Effects In Vitro and In Vivo by Targeting Src/Nuclear Factor (NF)-κB
by: Jiwon Jang, et al.
Published: (2020-05-01)

Src/NF-κB-Targeted Anti-Inflammatory Effects of Potentilla glabra var. Mandshurica (Maxim.) Hand.-Mazz. Ethanol Extract
by: Haeyeop Kim, et al.
Published: (2020-04-01)

Anti-inflammatory effect of torilidis fructus ethanol extract through inhibition of Src
by: Gyubyung Park, et al.
Published: (2017-01-01)

LOMIX, a Mixture of Flaxseed Linusorbs, Exerts Anti-Inflammatory Effects through Src and Syk in the NF-κB Pathway
by: Zubair Ahmed Ratan, et al.
Published: (2020-06-01)

Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum
by: Elgendy Khaled, et al.
Published: (2021-05-01)

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches
by: Mi Hee Park, et al.
Published: (2016-03-01)

Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells
by: H. M. Arif Ullah, et al.
Published: (2021-09-01)

Perilla frutescens Extracts Protects against Dextran Sulfate Sodium-Induced Murine Colitis: NF-κB, STAT3, and Nrf2 as Putative Targets
by: Deung Dae Park, et al.
Published: (2017-08-01)

Differences in anti-inflammatory effect of immature and mature of Rubus coreanus fruits on LPS-induced RAW 264.7 macrophages via NF-κB signal pathways
by: Kyung Hye Seo, et al.
Published: (2019-04-01)

Anti-Inflammatory Effects of <i>Berchemia floribunda</i> in LPS-Stimulated RAW264.7 Cells through Regulation of NF-κB and MAPKs Signaling Pathway
by: Hyun Ji Eo, et al.
Published: (2021-03-01)

NFκB gene expression survey in peripheral blood cell of Sardasht warfare agent victims 20 years after exposure to sulfur mustard
by: F. parvizpour, et al.
Published: (2011-09-01)

Lutonarin from Barley Seedlings Inhibits the Lipopolysacchride-Stimulated Inflammatory Response of RAW 264.7 Macrophages by Suppressing Nuclear Factor-κB Signaling
by: So-Yeun Woo, et al.
Published: (2021-03-01)

AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression
by: Hong-Chun Xiang, et al.
Published: (2019-02-01)

A Traditional Korean Diet with a Low Dietary Inflammatory Index Increases Anti-Inflammatory IL-10 and Decreases Pro-Inflammatory NF-κB in a Small Dietary Intervention Study
by: Phil-Kyung Shin, et al.
Published: (2020-08-01)

Cortisol modulates inflammatory responses in LPS-stimulated RAW264.7 cells via the NF-κB and MAPK pathways
by: Junsheng Dong, et al.
Published: (2018-01-01)

Anti-inflammatory effect of the hexane fraction from Orostachys japonicus in RAW 264.7 cells by suppression of NF-κB and PI3K-Akt signaling
by: Hyeong-Seon Lee, et al.
Published: (2013-07-01)

Lycopene mitigates atrazine-induced cardiac inflammation via blocking the NF-κB pathway and NO production
by: Xue-Nan Li, et al.
Published: (2017-02-01)

The Anti-Inflammatory Effect of Arginine-Vasopressin on Lipopolysaccharide-Induced IκBα/Nuclear Factor-κB Cascade
by: Jisoo Park, et al.
Published: (2015-08-01)

ISGylation Inhibits an LPS-Induced Inflammatory Response via the TLR4/NF-κB Signaling Pathway in Goat Endometrial Epithelial Cells
by: Jinbang Xiao, et al.
Published: (2021-09-01)

Anti-inflammatory effect of litsenolide B2 isolated from Litsea japonica fruit via suppressing NF-κB and MAPK pathways in LPS-induced RAW264.7 cells
by: Young-Min Ham, et al.
Published: (2015-03-01)

The effect of bitter gourd (Momordica charantia) ethanolic extract on inflammatory infiltrates and NF-κB activation in periodontitis
by: Aryudhi Armis, et al.
Published: (2019-12-01)

Synthesis and Identification of Novel Berberine Derivatives as Potent Inhibitors against TNF-α-Induced NF-κB Activation
by: Yan-Xiang Wang, et al.
Published: (2017-07-01)

Geraniin ameliorate experimental acute reflux esophagitis via NF-κB regulated anti-inflammatory activities in rats
by: Hyeon Hwa Nam, et al.
Published: (2019-03-01)

Nrf2‐Activating Bioactive Peptides Exert Anti‐Inflammatory Activity through Inhibition of the NF‐κB Pathway
by: Bindoli, A., et al.
Published: (2022)

Nrf2‐Activating Bioactive Peptides Exert Anti‐Inflammatory Activity through Inhibition of the NF‐κB Pathway
by: Bindoli, A., et al.
Published: (2022)

Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-κB Signaling Cascades
by: Md Badrul Alam, et al.
Published: (2020-07-01)

Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway
by: Luxi Cao, et al.
Published: (2020-07-01)

Effects of different doses of atorvastatin on NF-κB, inflammatory factors and insulin resistance in elderly patients with early diabetic nephropathy
by: Ying Liu, et al.
Published: (2016-01-01)

Protosappanin A protects against atherosclerosis via anti- hyperlipidemia, anti-inflammation and NF-κB signaling pathway in hyperlipidemic rabbits
by: Ying Huang, et al.
Published: (2018-01-01)

Ginkgolide B Alleviates Learning and Memory Impairment in Rats With Vascular Dementia by Reducing Neuroinflammation via Regulating NF-κB Pathway
by: Lijuan Huang, et al.
Published: (2021-06-01)

Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway
by: Zhixian Xu, et al.
Published: (2021-07-01)

Role of nuclear IκBs in inflammation regulation
by: Chiba Tomoki, et al.
Published: (2013-04-01)

Flavonoids derived from Exocarpium Citri Grandis inhibit LPS-induced inflammatory response via suppressing MAPK and NF-κB signalling pathways
by: Ying Peng, et al.
Published: (2019-01-01)

Overview of Research Development on the Role of NF-κB Signaling in Mastitis
by: Muhammad Zahoor Khan, et al.
Published: (2020-09-01)

Polyphenol-rich propolis extracts from China and Brazil exert anti-inflammatory effects by modulating ubiquitination of TRAF6 during the activation of NF-κB
by: Kai Wang, et al.
Published: (2015-12-01)

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients
by: Stamatia Papoutsopoulou, et al.
Published: (2019-09-01)

Dissecting the Role of NF-κb Protein Family and Its Regulators in Rheumatoid Arthritis Using Weighted Gene Co-Expression Network
by: Jamal S. M. Sabir, et al.
Published: (2019-11-01)