Single Cell Transcriptome Helps Better Understanding Crosstalk in Diabetic Kidney Disease

• Main Authors: Chunyang Du, Yunzhuo Ren, Guixin Li, Yan Yang, Zhe Yan, Fang Yao
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-08-01
• Series: Frontiers in Medicine
• Subjects: single-cell RNA sequencing; crosstalk; diabetic kidney disease; glomerulus; tubular epithelial cell
• Online Access: https://www.frontiersin.org/articles/10.3389/fmed.2021.657614/full

Years of research revealed that crosstalk extensively existed among kidney cells, cell factors and metabolites and played an important role in the development of diabetic kidney disease (DKD). In the last few years, single-cell RNA sequencing (scRNA-seq) technology provided new insight into cellular heterogeneity and genetic susceptibility regarding DKD at cell-specific level. The studies based on scRNA-seq enable a much deeper understanding of cell-specific processes such as interaction between cells. In this paper, we aim to review recent progress in single cell transcriptomic analyses of DKD, particularly highlighting on intra- or extra-glomerular cell crosstalk, cellular targets and potential therapeutic strategies for DKD.