IGF-I prevents glutamate-induced motor neuron programmed cell death

IGF-I prevents glutamate-induced motor neuron programmed cell death

Insulin-like growth factor I (IGF-I) is currently in clinical trials for treatment of amyotrophic lateral sclerosis (ALS), but little is known about how it promotes the survival of motor neurons. In the current study, we examined IGF-I-mediated neuroprotection in an in vitro model of ALS utilizing e...

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Bibliographic Details
Main Authors: Andrea M Vincent, Bret C Mobley, Andrew Hiller, Eva L Feldman
Format: Article
Language:English
Published: Elsevier 2004-07-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Apoptosis
Drug screening
Gene therapy
Insulin-like growth factor-I
Programmed cell death (PCD)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104000658

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