Usefulness of NT-proBNP in the follow-up of patients after myocardial infarction

• Main Authors: Radosavljević-Radovanović Mina, Radovanović Nebojša, Vasiljević Zorana, Marinković Jelena, Mitrović Predrag, Mrdović Igor, Stanković Sanja, Kružliak Peter, Beleslin Branko, Ušćumlić Ana, Kostić Jelena
• Format: Article
• Language: English
• Published: Society of Medical Biochemists of Serbia, Belgrade 2016-01-01
• Series: Journal of Medical Biochemistry
• Subjects: prognostic neurohumoral testing; postinfarction period; n-terminal pro-brain natriuretic peptide; myocardial infarction
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2016/1452-82581602158R.pdf

Background: Since serial analyses of NT-proBNP in patients with acute coronary syndromes have shown that levels measured during a chronic, later phase are a better predictor of prognosis and indicator of left ventricular function than the levels measured during an acute phase, we sought to assess the association of NT-proBNP measured 6 months after acute myocardial infarction (AMI), with traditional risk factors, characteristics of in-hospital and early postinfarction course, as well as its prognostic value and optimal cut-points in the ensuing 1-year follow-up. Methods: Fasting venous blood samples were drawn from 100 ambulatory patients and NT-proBNP concentrations in Lithium-heparin plasma were determined using a one-step enzyme immunoassay based on the "sandwich" principle on a Dimension RxL clinical chemistry system (DADE BehringSiemens). Patients were followed-up for the next 1 year, for the occurrence of new cardiac events. Results: Median (IQR) level of NT-proBNP was 521 (335-1095) pg/mL. Highest values were mostly associated with cardiac events during the first 6 months after AMI. Negative association with reperfusion therapy for index infarction confirmed its long-term beneficial effect. In the next one-year follow-up of stable patients, multivariate Cox regression analysis revealed the independent prognostic value of NTproBNP for new-onset heart failure prediction (p=0.014), as well as for new coronary events prediction (p=0.035). Calculation of the AUCs revealed the optimal NT-proBNP cut-points of 800 pg/mL and 516 pg/mL, respectively.