Nano TiO2/SiO2: An efficient and reusable catalyst for the synthesis of oxindole derivatives
Nano TiO2 supported on SiO2 (Nano TiO2/SiO2) as a solid Lewis acid, was found to be an effective and reusable catalyst for the condensation reaction of indoles with isatins to afford the corresponding bis(indolyl)oxindoles at 50 °C under solvent-free conditions. The efficacy of the catalyst was also...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-01-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610314001306 |
| Summary: | Nano TiO2 supported on SiO2 (Nano TiO2/SiO2) as a solid Lewis acid, was found to be an effective and reusable catalyst for the condensation reaction of indoles with isatins to afford the corresponding bis(indolyl)oxindoles at 50 °C under solvent-free conditions. The efficacy of the catalyst was also examined in the reaction of pyrrole and 3-methylindole with isatin. The catalyst has been recovered and its reusability confirmed in 5 runs. A plausible mechanism of condensation has also been suggested. |
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| ISSN: | 1319-6103 |