Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease

The effect of inflammatory bowel disease (IBD) on the density of galanin - immunoreactive (GAL-IR) nerve fibers was determined in the mucosa of canine duodenum, jejunum, and descending colon. Fiber density was evaluated by a single immunofluorescence method in biopsy specimens obtained from healthy...

Full description

Bibliographic Details
Main Authors:	Rychlik Andrzej, Gonkowski Sławomir, Nowicki Marcin, Całka Jarosław, Szweda Marta
Format:	Article
Language:	English
Published:	Sciendo 2015-03-01
Series:	Bulletin of the Veterinary Institute in Pulawy
Subjects:	dogs inflammatory bowel disease digestive tract nervous system galanin immunohistochemistry
Online Access:	https://doi.org/10.1515/bvip-2015-0021

id	doaj-4e67e0e18e9f412192b66b11dff837c8
record_format	Article
spelling	doaj-4e67e0e18e9f412192b66b11dff837c82021-09-22T06:13:02ZengSciendoBulletin of the Veterinary Institute in Pulawy2300-32352015-03-0159114314810.1515/bvip-2015-0021bvip-2015-0021Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel DiseaseRychlik Andrzej0Gonkowski Sławomir1Nowicki Marcin2Całka Jarosław3Szweda Marta4Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957Olsztyn, PolandDepartment of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957Olsztyn, PolandDepartment of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957Olsztyn, PolandDepartment of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957Olsztyn, PolandDepartment of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957Olsztyn, PolandThe effect of inflammatory bowel disease (IBD) on the density of galanin - immunoreactive (GAL-IR) nerve fibers was determined in the mucosa of canine duodenum, jejunum, and descending colon. Fiber density was evaluated by a single immunofluorescence method in biopsy specimens obtained from healthy dogs and patients with variable severity of the disease. The density of GAL-IR nerve fibers was determined by the semi-quantitative method by counting fibers in the field of view (0.l mm2). Fiber density was higher in dogs with moderate and severe IBD than in healthy animals. The results of the study suggest that GAL present in intestinal nerve fibers could play a role in the pathogenesis and development of canine IBD.https://doi.org/10.1515/bvip-2015-0021dogsinflammatory bowel diseasedigestive tractnervous systemgalaninimmunohistochemistry
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rychlik Andrzej Gonkowski Sławomir Nowicki Marcin Całka Jarosław Szweda Marta
spellingShingle	Rychlik Andrzej Gonkowski Sławomir Nowicki Marcin Całka Jarosław Szweda Marta Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease Bulletin of the Veterinary Institute in Pulawy dogs inflammatory bowel disease digestive tract nervous system galanin immunohistochemistry
author_facet	Rychlik Andrzej Gonkowski Sławomir Nowicki Marcin Całka Jarosław Szweda Marta
author_sort	Rychlik Andrzej
title	Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease
title_short	Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease
title_full	Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease
title_fullStr	Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease
title_full_unstemmed	Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease
title_sort	galanin - immunoreactive nerve fibers in the mucosal layer of the canine gastrointestinal tract during inflammatory bowel disease
publisher	Sciendo
series	Bulletin of the Veterinary Institute in Pulawy
issn	2300-3235
publishDate	2015-03-01
description	The effect of inflammatory bowel disease (IBD) on the density of galanin - immunoreactive (GAL-IR) nerve fibers was determined in the mucosa of canine duodenum, jejunum, and descending colon. Fiber density was evaluated by a single immunofluorescence method in biopsy specimens obtained from healthy dogs and patients with variable severity of the disease. The density of GAL-IR nerve fibers was determined by the semi-quantitative method by counting fibers in the field of view (0.l mm2). Fiber density was higher in dogs with moderate and severe IBD than in healthy animals. The results of the study suggest that GAL present in intestinal nerve fibers could play a role in the pathogenesis and development of canine IBD.
topic	dogs inflammatory bowel disease digestive tract nervous system galanin immunohistochemistry
url	https://doi.org/10.1515/bvip-2015-0021
work_keys_str_mv	AT rychlikandrzej galaninimmunoreactivenervefibersinthemucosallayerofthecaninegastrointestinaltractduringinflammatoryboweldisease AT gonkowskisławomir galaninimmunoreactivenervefibersinthemucosallayerofthecaninegastrointestinaltractduringinflammatoryboweldisease AT nowickimarcin galaninimmunoreactivenervefibersinthemucosallayerofthecaninegastrointestinaltractduringinflammatoryboweldisease AT całkajarosław galaninimmunoreactivenervefibersinthemucosallayerofthecaninegastrointestinaltractduringinflammatoryboweldisease AT szwedamarta galaninimmunoreactivenervefibersinthemucosallayerofthecaninegastrointestinaltractduringinflammatoryboweldisease
_version_	1717371835372273664

Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease

Similar Items