Aldehyde Dehydrogenase-2 Attenuates Myocardial Remodeling and Contractile Dysfunction Induced by a High-Fat Diet

Aldehyde Dehydrogenase-2 Attenuates Myocardial Remodeling and Contractile Dysfunction Induced by a High-Fat Diet

Background/Aims: Consumption of a high-fat (HF) diet exacerbates metabolic cardiomyopathy through lipotoxic mechanisms. In this study, we explored the role of aldehyde dehydrogenase-2 (ALDH2) in myocardial damage induced by a HF diet. Methods: Wild-type C57 BL/6J mice were fed a HF diet or control d...

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Bibliographic Details
Main Authors: Chuanbao Li, Xiaoxing Li, Ying Chang, Lang Zhao, Baoshan Liu, Shujian Wei, Feng Xu, Yun Zhang, Yuguo Chen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Metabolic syndrome
Myocardial remodeling
Apoptosis
ALDH2
Mice
Online Access:https://www.karger.com/Article/FullText/492506

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