Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity
Toxoplasma gondii (T. gondii) infects central nervous tissue and is kept in relative dormancy by a healthy immune system. Sleep disturbances have been found to precipitate mental illness, suicidal behavior and car accidents, which have been previously linked to T. gondii as well. We speculated that...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-12-01
|
| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pterid-2017-0010 |
| id |
doaj-4e5a920de01a48439842ca523179b3de |
|---|---|
| record_format |
Article |
| spelling |
doaj-4e5a920de01a48439842ca523179b3de2021-09-05T13:59:57ZengDe GruyterPteridines0933-48072195-47202017-12-01283-419520410.1515/pterid-2017-0010Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensityAhmad Zaki0Moustafa Yara W.1Stiller John W.2Pavlovich Mary A.3Raheja Uttam K.4Gragnoli Claudia5Snitker Soren6Nazem Sarra7Dagdag Aline8Fang Beverly9Fuchs Dietmar10Lowry Christopher A.11Postolache Teodor T.12Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USAMood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USAMood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USADivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USAMood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USADivision of Endocrinology, Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USADivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USARocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Denver, CO, USAMood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USAMood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USADivision of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, AustriaDepartment of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USAMood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USAToxoplasma gondii (T. gondii) infects central nervous tissue and is kept in relative dormancy by a healthy immune system. Sleep disturbances have been found to precipitate mental illness, suicidal behavior and car accidents, which have been previously linked to T. gondii as well. We speculated that if sleep disruption, particularly insomnia, would mediate, at least partly, the link between T. gondii infection and related behavioral dysregulation, then we would be able to identify significant associations between sleep disruption and T. gondii. The mechanisms for such an association may involve dopamine (DA) production by T. gondii, or collateral effects of immune activation necessary to keep T. gondii in check. Sleep questionnaires from 2031 Old Order Amish were analyzed in relationship to T. gondii-IgG antibodies measured by enzyme-linked immunosorbent assay (ELISA). Toxoplasma gondii seropositivity and serointensity were not associated with any of the sleep latency variables or Epworth Sleepiness Scale (ESS). A secondary analysis identified, after adjustment for age group, a statistical trend toward shorter sleep duration in seropositive men (p=0.07). In conclusion, it is unlikely that sleep disruption mediates links between T. gondii and mental illness or behavioral dysregulation. Trending gender differences in associations between T. gondii and shorter sleep need further investigation.https://doi.org/10.1515/pterid-2017-0010epworth sleepiness scaleexcessive daytime sleepinessinsomniaold order amishsleep durationtoxoplasma gondii |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ahmad Zaki Moustafa Yara W. Stiller John W. Pavlovich Mary A. Raheja Uttam K. Gragnoli Claudia Snitker Soren Nazem Sarra Dagdag Aline Fang Beverly Fuchs Dietmar Lowry Christopher A. Postolache Teodor T. |
| spellingShingle |
Ahmad Zaki Moustafa Yara W. Stiller John W. Pavlovich Mary A. Raheja Uttam K. Gragnoli Claudia Snitker Soren Nazem Sarra Dagdag Aline Fang Beverly Fuchs Dietmar Lowry Christopher A. Postolache Teodor T. Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity Pteridines epworth sleepiness scale excessive daytime sleepiness insomnia old order amish sleep duration toxoplasma gondii |
| author_facet |
Ahmad Zaki Moustafa Yara W. Stiller John W. Pavlovich Mary A. Raheja Uttam K. Gragnoli Claudia Snitker Soren Nazem Sarra Dagdag Aline Fang Beverly Fuchs Dietmar Lowry Christopher A. Postolache Teodor T. |
| author_sort |
Ahmad Zaki |
| title |
Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity |
| title_short |
Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity |
| title_full |
Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity |
| title_fullStr |
Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity |
| title_full_unstemmed |
Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity |
| title_sort |
sleep onset insomnia, daytime sleepiness and sleep duration in relationship to toxoplasma gondii igg seropositivity and serointensity |
| publisher |
De Gruyter |
| series |
Pteridines |
| issn |
0933-4807 2195-4720 |
| publishDate |
2017-12-01 |
| description |
Toxoplasma gondii (T. gondii) infects central nervous tissue and is kept in relative dormancy by a healthy immune system. Sleep disturbances have been found to precipitate mental illness, suicidal behavior and car accidents, which have been previously linked to T. gondii as well. We speculated that if sleep disruption, particularly insomnia, would mediate, at least partly, the link between T. gondii infection and related behavioral dysregulation, then we would be able to identify significant associations between sleep disruption and T. gondii. The mechanisms for such an association may involve dopamine (DA) production by T. gondii, or collateral effects of immune activation necessary to keep T. gondii in check. Sleep questionnaires from 2031 Old Order Amish were analyzed in relationship to T. gondii-IgG antibodies measured by enzyme-linked immunosorbent assay (ELISA). Toxoplasma gondii seropositivity and serointensity were not associated with any of the sleep latency variables or Epworth Sleepiness Scale (ESS). A secondary analysis identified, after adjustment for age group, a statistical trend toward shorter sleep duration in seropositive men (p=0.07). In conclusion, it is unlikely that sleep disruption mediates links between T. gondii and mental illness or behavioral dysregulation. Trending gender differences in associations between T. gondii and shorter sleep need further investigation. |
| topic |
epworth sleepiness scale excessive daytime sleepiness insomnia old order amish sleep duration toxoplasma gondii |
| url |
https://doi.org/10.1515/pterid-2017-0010 |
| work_keys_str_mv |
AT ahmadzaki sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT moustafayaraw sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT stillerjohnw sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT pavlovichmarya sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT rahejauttamk sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT gragnoliclaudia sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT snitkersoren sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT nazemsarra sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT dagdagaline sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT fangbeverly sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT fuchsdietmar sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT lowrychristophera sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity AT postolacheteodort sleeponsetinsomniadaytimesleepinessandsleepdurationinrelationshiptotoxoplasmagondiiiggseropositivityandserointensity |
| _version_ |
1717812715027693568 |