Preparation and Characterization of Topical Letrozole Nanoemulsion for Breast Cancer

• Main Authors: Ihab D. Hammodi, Shaimaa N. Abd Alhammid
• Format: Article
• Language: English
• Published: College of Pharmacy University of Baghdad 2020-06-01
• Series: Iraqi Journal of Pharmaceutical Sciences
• Online Access: http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/989

Letrozole (LZL) is a non-steroidal competitive aromatase enzyme system inhibitor. The aim of this study is to improve the permeation of LZL through the skin by preparing as nanoemulsion using various numbers of oils, surfactants and co-surfactant with deionized water. Based on solubility studies, mixtures of oleic acid oil and tween 80/ transcutol p as surfactant/co-surfactant (Smix) in different percentages were used to prepare nanoemulsions (NS). Therefore, 9 formulae of (o/w) LZL NS were formulated, then pseudo-ternary phase diagram was used as a useful tool to evaluate the NS domain at Smix ratios: 1:1, 2:1 and 3:1.