Preparation and Characterization of Topical Letrozole Nanoemulsion for Breast Cancer
Letrozole (LZL) is a non-steroidal competitive aromatase enzyme system inhibitor. The aim of this study is to improve the permeation of LZL through the skin by preparing as nanoemulsion using various numbers of oils, surfactants and co-surfactant with deionized water. Based on solubility studies, mi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2020-06-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Online Access: | http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/989 |
| Summary: | Letrozole (LZL) is a non-steroidal competitive aromatase enzyme system inhibitor. The aim of this study is to improve the permeation of LZL through the skin by preparing as nanoemulsion using various numbers of oils, surfactants and co-surfactant with deionized water. Based on solubility studies, mixtures of oleic acid oil and tween 80/ transcutol p as surfactant/co-surfactant (Smix) in different percentages were used to prepare nanoemulsions (NS). Therefore, 9 formulae of (o/w) LZL NS were formulated, then pseudo-ternary phase diagram was used as a useful tool to evaluate the NS domain at Smix ratios: 1:1, 2:1 and 3:1. |
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| ISSN: | 2521-3512 1683-3597 |