High-Resolution Respirometry Reveals MPP<sup>+</sup> Mitochondrial Toxicity Mechanism in a Cellular Model of Parkinson’s Disease

High-Resolution Respirometry Reveals MPP<sup>+</sup> Mitochondrial Toxicity Mechanism in a Cellular Model of Parkinson’s Disease

MPP<sup>+</sup> is the active metabolite of MPTP, a molecule structurally similar to the herbicide Paraquat, known to injure the dopaminergic neurons of the nigrostriatal system in Parkinson’s disease models. Within the cells, MPP<sup>+</sup> accumulates in mitochondria where...

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Bibliographic Details
Main Authors:	Pierpaolo Risiglione, Loredana Leggio, Salvatore A. M. Cubisino, Simona Reina, Greta Paternò, Bianca Marchetti, Andrea Magrì, Nunzio Iraci, Angela Messina
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	International Journal of Molecular Sciences
Subjects:	MPP<sup>+</sup> mitochondria Parkinson’s disease high-resolution respirometry SH-SY5Y cells
Online Access:	https://www.mdpi.com/1422-0067/21/21/7809

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