Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts

Yeasts are promising industrial hosts for sustainable production of fuels and chemicals. Apart from efficient bioethanol production, yeasts have recently demonstrated their potential for biodiesel production from renewable resources. The fuel-oriented product profiles of yeasts are now expanding to...

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Main Authors:	Jiwon Kim, Phuong Hoang Nguyen Tran, Sun-Mi Lee
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-12-01
Series:	Frontiers in Bioengineering and Biotechnology
Subjects:	non-native chemicals Saccharomyces cerevisiae Yarrowia lipolytica yeast engineering biorefinery
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2020.594061/full

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spelling	doaj-4e504b9da5784872b6612e6ef804e84e2020-12-14T05:00:59ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-12-01810.3389/fbioe.2020.594061594061Current Challenges and Opportunities in Non-native Chemical Production by Engineered YeastsJiwon Kim0Jiwon Kim1Phuong Hoang Nguyen Tran2Phuong Hoang Nguyen Tran3Sun-Mi Lee4Sun-Mi Lee5Sun-Mi Lee6Clean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, South KoreaDepartment of Biotechnology, Korea University, Seoul, South KoreaClean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, South KoreaDivision of Energy and Environment Technology, University of Science and Technology (UST), Daejeon, South KoreaClean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, South KoreaDivision of Energy and Environment Technology, University of Science and Technology (UST), Daejeon, South KoreaGreen School, Korea University, Seoul, South KoreaYeasts are promising industrial hosts for sustainable production of fuels and chemicals. Apart from efficient bioethanol production, yeasts have recently demonstrated their potential for biodiesel production from renewable resources. The fuel-oriented product profiles of yeasts are now expanding to include non-native chemicals with the advances in synthetic biology. In this review, current challenges and opportunities in yeast engineering for sustainable production of non-native chemicals will be discussed, with a focus on the comparative evaluation of a bioethanol-producing Saccharomyces cerevisiae strain and a biodiesel-producing Yarrowia lipolytica strain. Synthetic pathways diverging from the distinctive cellular metabolism of these yeasts guide future directions for product-specific engineering strategies for the sustainable production of non-native chemicals on an industrial scale.https://www.frontiersin.org/articles/10.3389/fbioe.2020.594061/fullnon-native chemicalsSaccharomyces cerevisiaeYarrowia lipolyticayeast engineeringbiorefinery
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jiwon Kim Jiwon Kim Phuong Hoang Nguyen Tran Phuong Hoang Nguyen Tran Sun-Mi Lee Sun-Mi Lee Sun-Mi Lee
spellingShingle	Jiwon Kim Jiwon Kim Phuong Hoang Nguyen Tran Phuong Hoang Nguyen Tran Sun-Mi Lee Sun-Mi Lee Sun-Mi Lee Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts Frontiers in Bioengineering and Biotechnology non-native chemicals Saccharomyces cerevisiae Yarrowia lipolytica yeast engineering biorefinery
author_facet	Jiwon Kim Jiwon Kim Phuong Hoang Nguyen Tran Phuong Hoang Nguyen Tran Sun-Mi Lee Sun-Mi Lee Sun-Mi Lee
author_sort	Jiwon Kim
title	Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts
title_short	Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts
title_full	Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts
title_fullStr	Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts
title_full_unstemmed	Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts
title_sort	current challenges and opportunities in non-native chemical production by engineered yeasts
publisher	Frontiers Media S.A.
series	Frontiers in Bioengineering and Biotechnology
issn	2296-4185
publishDate	2020-12-01
description	Yeasts are promising industrial hosts for sustainable production of fuels and chemicals. Apart from efficient bioethanol production, yeasts have recently demonstrated their potential for biodiesel production from renewable resources. The fuel-oriented product profiles of yeasts are now expanding to include non-native chemicals with the advances in synthetic biology. In this review, current challenges and opportunities in yeast engineering for sustainable production of non-native chemicals will be discussed, with a focus on the comparative evaluation of a bioethanol-producing Saccharomyces cerevisiae strain and a biodiesel-producing Yarrowia lipolytica strain. Synthetic pathways diverging from the distinctive cellular metabolism of these yeasts guide future directions for product-specific engineering strategies for the sustainable production of non-native chemicals on an industrial scale.
topic	non-native chemicals Saccharomyces cerevisiae Yarrowia lipolytica yeast engineering biorefinery
url	https://www.frontiersin.org/articles/10.3389/fbioe.2020.594061/full
work_keys_str_mv	AT jiwonkim currentchallengesandopportunitiesinnonnativechemicalproductionbyengineeredyeasts AT jiwonkim currentchallengesandopportunitiesinnonnativechemicalproductionbyengineeredyeasts AT phuonghoangnguyentran currentchallengesandopportunitiesinnonnativechemicalproductionbyengineeredyeasts AT phuonghoangnguyentran currentchallengesandopportunitiesinnonnativechemicalproductionbyengineeredyeasts AT sunmilee currentchallengesandopportunitiesinnonnativechemicalproductionbyengineeredyeasts AT sunmilee currentchallengesandopportunitiesinnonnativechemicalproductionbyengineeredyeasts AT sunmilee currentchallengesandopportunitiesinnonnativechemicalproductionbyengineeredyeasts
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Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts

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