Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma
Introduction: Nephrilin peptide, a designed inhibitor of Rictor complex, modulates systemic responses to trauma, alleviating clinically relevant variables in a rat scald model and sepsis mortality in a mouse model. This study explores the possibility that chemical conjugation of small molecules to t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-07-01
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| Series: | Burns Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468912220300304 |