Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation

Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation

Summary: Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development. However, precisely how deletion of Prdm12 during development or adulthood affects nociception is unknown. Here, we employ...

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Bibliographic Details
Main Authors: Mark A. Landy, Megan Goyal, Katherine M. Casey, Chen Liu, Helen C. Lai
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
Prdm12
pain
nociceptors
mouse
behavior
congenital insensitivity to pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002278

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