Exosomal Proteome Profiling: A Potential Multi-Marker Cellular Phenotyping Tool to Characterize Hypoxia-Induced Radiation Resistance in Breast Cancer

Exosomal Proteome Profiling: A Potential Multi-Marker Cellular Phenotyping Tool to Characterize Hypoxia-Induced Radiation Resistance in Breast Cancer

Radiation and drug resistance are significant challenges in the treatment of locally advanced, recurrent and metastatic breast cancer that contribute to mortality. Clinically, radiotherapy requires oxygen to generate cytotoxic free radicals that cause DNA damage and allow that damage to become fixed...

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Bibliographic Details
Main Authors: Stefani N. Thomas, Zhongping Liao, David Clark, Yangyi Chen, Ramin Samadani, Li Mao, David K. Ann, Janet E. Baulch, Paul Shapiro, Austin J. Yang
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Proteomes
Subjects:
hypoxia
radiation
breast cancer
tumor microenvironment
exosomes
proteomics
Online Access:http://www.mdpi.com/2227-7382/1/2/87

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