Age-related Hearing Impairment and the Triad of Acquired Hearing Loss

Understanding underlying pathological mechanisms is prerequisite for a sensible design of protective therapies against hearing loss. The triad of age-related, noise-generated, and drug-induced hearing loss ¬¬displays intriguing similarities in some cellular responses of cochlear sensory cells such a...

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Main Authors: Chao-Hui eYang, Thomas eSchrepfer, Jochen eSchacht
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00276/full
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spelling doaj-4e36aeb8b8c1407e9a53a5ab886878d42020-11-25T00:55:13ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-07-01910.3389/fncel.2015.00276132506Age-related Hearing Impairment and the Triad of Acquired Hearing LossChao-Hui eYang0Chao-Hui eYang1Thomas eSchrepfer2Jochen eSchacht3University of MichiganKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineUniversity of MichiganUniversity of MichiganUnderstanding underlying pathological mechanisms is prerequisite for a sensible design of protective therapies against hearing loss. The triad of age-related, noise-generated, and drug-induced hearing loss ¬¬displays intriguing similarities in some cellular responses of cochlear sensory cells such as a potential involvement of reactive oxygen species and apoptotic and necrotic cell death. On the other hand, detailed studies have revealed that molecular pathways are considerably complex and, importantly, it has become clear that pharmacological protection successful against one form of hearing loss will not necessarily protect against another. This review will summarize pathological and pathophysiological features of age-related hearing impairment (ARHI) in human and animal models and address selected aspects of the commonality (or lack thereof) of cellular responses in ARHI to drugs and noise.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00276/fullPresbycusisototoxicityaminoglycoside antibioticsAcquired hearing lossNoise trauma
collection DOAJ
language English
format Article
sources DOAJ
author Chao-Hui eYang
Chao-Hui eYang
Thomas eSchrepfer
Jochen eSchacht
spellingShingle Chao-Hui eYang
Chao-Hui eYang
Thomas eSchrepfer
Jochen eSchacht
Age-related Hearing Impairment and the Triad of Acquired Hearing Loss
Frontiers in Cellular Neuroscience
Presbycusis
ototoxicity
aminoglycoside antibiotics
Acquired hearing loss
Noise trauma
author_facet Chao-Hui eYang
Chao-Hui eYang
Thomas eSchrepfer
Jochen eSchacht
author_sort Chao-Hui eYang
title Age-related Hearing Impairment and the Triad of Acquired Hearing Loss
title_short Age-related Hearing Impairment and the Triad of Acquired Hearing Loss
title_full Age-related Hearing Impairment and the Triad of Acquired Hearing Loss
title_fullStr Age-related Hearing Impairment and the Triad of Acquired Hearing Loss
title_full_unstemmed Age-related Hearing Impairment and the Triad of Acquired Hearing Loss
title_sort age-related hearing impairment and the triad of acquired hearing loss
publisher Frontiers Media S.A.
series Frontiers in Cellular Neuroscience
issn 1662-5102
publishDate 2015-07-01
description Understanding underlying pathological mechanisms is prerequisite for a sensible design of protective therapies against hearing loss. The triad of age-related, noise-generated, and drug-induced hearing loss ¬¬displays intriguing similarities in some cellular responses of cochlear sensory cells such as a potential involvement of reactive oxygen species and apoptotic and necrotic cell death. On the other hand, detailed studies have revealed that molecular pathways are considerably complex and, importantly, it has become clear that pharmacological protection successful against one form of hearing loss will not necessarily protect against another. This review will summarize pathological and pathophysiological features of age-related hearing impairment (ARHI) in human and animal models and address selected aspects of the commonality (or lack thereof) of cellular responses in ARHI to drugs and noise.
topic Presbycusis
ototoxicity
aminoglycoside antibiotics
Acquired hearing loss
Noise trauma
url http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00276/full
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