The contribution of <it>CHEK2 </it>to the <it>TP53</it>-negative Li-Fraumeni phenotype

The contribution of <it>CHEK2 </it>to the <it>TP53</it>-negative Li-Fraumeni phenotype

<p>Abstract</p> <p>Background</p> <p><it>CHEK2 </it>has previously been excluded as a major cause of Li-Fraumeni syndrome (LFS). One particular <it>CHEK2 </it>germline mutation, c.1100delC, has been shown to be associated with elevated breast can...

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Bibliographic Details
Main Authors: Ruijs Marielle WG, Broeks Annegien, Menko Fred H, Ausems Margreet GEM, Wagner Anja, Oldenburg Rogier, Meijers-Heijboer Hanne, van't Veer Laura J, Verhoef Senno
Format: Article
Language:English
Published: BMC 2009-02-01
Series:Hereditary Cancer in Clinical Practice
Online Access:http://www.hccpjournal.com/content/7/1/4

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