Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19

• Main Authors: Karel F. A. Van Damme, Simon Tavernier, Nele Van Roy, Elisabeth De Leeuw, Jozefien Declercq, Cédric Bosteels, Bastiaan Maes, Marieke De Bruyne, Delfien Bogaert, Victor Bosteels, Levi Hoste, Leslie Naesens, Piet Maes, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Pieter Depuydt, Eva Van Braeckel, Filomeen Haerynck, Bart N. Lambrecht
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-11-01
• Series: Frontiers in Immunology
• Subjects: convalescent plasma; COVID-19; common variable immunodeficiency disorders; immunodeficiencies; case report
• Online Access: https://www.frontiersin.org/articles/10.3389/fimmu.2020.596761/full
• ISSN: 1664-3224

The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient’s condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.