Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome Analysis

Cardiac Troponin I (cTnI) levels are considered an important diagnostic tool in acute coronary events. However, there is controversy over their sensitivity, specificity and prognostic value in haemodialysis (HD) patients. The aim of this study was to explore the behaviour and prognostic value of car...

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Main Authors: Carmen Cecilia Almonacid-Urrego, Jorge de Jesús Cantillo-Turbay, María Jesús Tuñón
Format: Article
Language:English
Published: Universidad Colegio Mayor de Cundinamarca 2009-06-01
Series:NOVA
Subjects:
Online Access:https://revistas.unicolmayor.edu.co/index.php/nova/article/view/126
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spelling doaj-4e2588aacb0a433bb1e482fced639f022020-11-24T21:54:52ZengUniversidad Colegio Mayor de CundinamarcaNOVA1794-24702462-94482009-06-0171110.22490/24629448.415126Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome AnalysisCarmen Cecilia Almonacid-UrregoJorge de Jesús Cantillo-TurbayMaría Jesús TuñónCardiac Troponin I (cTnI) levels are considered an important diagnostic tool in acute coronary events. However, there is controversy over their sensitivity, specificity and prognostic value in haemodialysis (HD) patients. The aim of this study was to explore the behaviour and prognostic value of cardiac troponin I in HD patients. Thirty-four asymptomatic patients undergoing long-term haemodialysis were studied. Samples of blood were collected at the start of the study (pre- and post-dialysis serum), after three years (pre-dialysis serum and plasma, with and without the addition of heterophilic antibody-blocking reagent (HBR) and after five years (pre-dialysis serum).   Quantitative cardiac troponin I was measured with an AxSYM cTnI micro-particle enzyme immuno-assay and qualitative cTnI with a Hexagon Troponin immuno-chromatographic one-step test. It did not prove possible to detect any significant association between pre- and post-dialysis cTnI levels.   Comparison of results for serum and heparin plasma revealed no statistically significant difference between the level of cTnI and the mean values for plasma and serum with and without the addition of HBR. The cTnI concentrations in the samples without added HBR were lower than in those with HBR, but no statistically significant difference between the mean for cTnI and the mean of samples with and without added HBR was observed. During the study, 35.2% of the population died. A positive association was observed between the cTnI values in the patients still living and those patients who died from ischaemic cardiomyopathy (p = 0.039).   The crude risk of death by cardiovascular disease was increased eight-fold (the 95% confidence interval being 1.2 to 51.1) in patients with a cTnI concentration greater than 0.04 ng/mL. Levels of cTnI may reflect occult myocardial ischemia and identify haemodialysis patients who face a greater risk of death.https://revistas.unicolmayor.edu.co/index.php/nova/article/view/126Cardiac biomarkersCardiac troponin IChronic renal failureHaemodialysis mortalityMyocardial injuryPrognostic value of cardiac troponin I
collection DOAJ
language English
format Article
sources DOAJ
author Carmen Cecilia Almonacid-Urrego
Jorge de Jesús Cantillo-Turbay
María Jesús Tuñón
spellingShingle Carmen Cecilia Almonacid-Urrego
Jorge de Jesús Cantillo-Turbay
María Jesús Tuñón
Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome Analysis
NOVA
Cardiac biomarkers
Cardiac troponin I
Chronic renal failure
Haemodialysis mortality
Myocardial injury
Prognostic value of cardiac troponin I
author_facet Carmen Cecilia Almonacid-Urrego
Jorge de Jesús Cantillo-Turbay
María Jesús Tuñón
author_sort Carmen Cecilia Almonacid-Urrego
title Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome Analysis
title_short Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome Analysis
title_full Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome Analysis
title_fullStr Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome Analysis
title_full_unstemmed Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome Analysis
title_sort behaviour and prognostic value of serum cardiac troponin i in patients with end-stage renal disease undergoing long-term haemodialysis. a five-year outcome analysis
publisher Universidad Colegio Mayor de Cundinamarca
series NOVA
issn 1794-2470
2462-9448
publishDate 2009-06-01
description Cardiac Troponin I (cTnI) levels are considered an important diagnostic tool in acute coronary events. However, there is controversy over their sensitivity, specificity and prognostic value in haemodialysis (HD) patients. The aim of this study was to explore the behaviour and prognostic value of cardiac troponin I in HD patients. Thirty-four asymptomatic patients undergoing long-term haemodialysis were studied. Samples of blood were collected at the start of the study (pre- and post-dialysis serum), after three years (pre-dialysis serum and plasma, with and without the addition of heterophilic antibody-blocking reagent (HBR) and after five years (pre-dialysis serum).   Quantitative cardiac troponin I was measured with an AxSYM cTnI micro-particle enzyme immuno-assay and qualitative cTnI with a Hexagon Troponin immuno-chromatographic one-step test. It did not prove possible to detect any significant association between pre- and post-dialysis cTnI levels.   Comparison of results for serum and heparin plasma revealed no statistically significant difference between the level of cTnI and the mean values for plasma and serum with and without the addition of HBR. The cTnI concentrations in the samples without added HBR were lower than in those with HBR, but no statistically significant difference between the mean for cTnI and the mean of samples with and without added HBR was observed. During the study, 35.2% of the population died. A positive association was observed between the cTnI values in the patients still living and those patients who died from ischaemic cardiomyopathy (p = 0.039).   The crude risk of death by cardiovascular disease was increased eight-fold (the 95% confidence interval being 1.2 to 51.1) in patients with a cTnI concentration greater than 0.04 ng/mL. Levels of cTnI may reflect occult myocardial ischemia and identify haemodialysis patients who face a greater risk of death.
topic Cardiac biomarkers
Cardiac troponin I
Chronic renal failure
Haemodialysis mortality
Myocardial injury
Prognostic value of cardiac troponin I
url https://revistas.unicolmayor.edu.co/index.php/nova/article/view/126
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