Metformin Restores the Drug Sensitivity of MCF-7 Cells Resistant Derivates via the Cooperative Modulation of Growth and Apoptotic-Related Pathways

Metformin Restores the Drug Sensitivity of MCF-7 Cells Resistant Derivates via the Cooperative Modulation of Growth and Apoptotic-Related Pathways

The phenomenon of the primary or acquired resistance of cancer cells to antitumor drugs is among the key problems of oncology. For breast cancer, the phenomenon of the resistance to hormonal or target therapy may be based on the numerous mechanisms including the loss or mutation of estrogen receptor...

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Bibliographic Details
Main Authors: Danila Sorokin, Yuri Shchegolev, Alexander Scherbakov, Oxana Ryabaya, Margarita Gudkova, Lev Berstein, Mikhail Krasil’nikov
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceuticals
Subjects:
metformin
resistance
cancer
AP-1—the transcription factor activator protein 1 (IPR000837)
NF-κB—the nuclear factor kappa-light-chain-enhancer of activated B cells (IPR030495)
breast cancer
Online Access:https://www.mdpi.com/1424-8247/13/9/206

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