Predicting the evolution of antibiotic resistance

<p>Abstract</p> <p>Mutations causing antibiotic resistance are often associated with a cost in the absence of antibiotics. Surprisingly, a new study found that bacteria adapting to increased temperature became resistant to rifampicin. By studying the consequences of the involved mu...

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Bibliographic Details
Main Authors: Schenk Martijn F, de Visser J Arjan GM
Format: Article
Language:English
Published: BMC 2013-02-01
Series:BMC Biology
Online Access:http://www.biomedcentral.com/1741-7007/11/14
Description
Summary:<p>Abstract</p> <p>Mutations causing antibiotic resistance are often associated with a cost in the absence of antibiotics. Surprisingly, a new study found that bacteria adapting to increased temperature became resistant to rifampicin. By studying the consequences of the involved mutations in different conditions and genetic backgrounds, the authors illustrate how knowledge of two fundamental genetic properties, pleiotropy and epistasis, may help to predict the evolution of antibiotic resistance.</p> <p>See research article <url>http://www.biomedcentral.com/1471-2148/13/50</url></p>
ISSN:1741-7007