Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding...

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Main Authors:	Gregory J. Fonseca, Jenhan Tao, Emma M. Westin, Sascha H. Duttke, Nathanael J. Spann, Tobias Strid, Zeyang Shen, Joshua D. Stender, Mashito Sakai, Verena M. Link, Christopher Benner, Christopher K. Glass
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-08236-0

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spelling	doaj-4dfc6b7b8a3849c7bce7ab3e8395079f2021-05-11T12:07:05ZengNature Publishing GroupNature Communications2041-17232019-01-0110111610.1038/s41467-018-08236-0Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophagesGregory J. Fonseca0Jenhan Tao1Emma M. Westin2Sascha H. Duttke3Nathanael J. Spann4Tobias Strid5Zeyang Shen6Joshua D. Stender7Mashito Sakai8Verena M. Link9Christopher Benner10Christopher K. Glass11Department of Cellular and Molecular Medicine, School of Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, School of Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, School of Medicine, University of California San DiegoDepartment of Medicine, School of Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, School of Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, School of Medicine, University of California San DiegoDepartment of Bioengineering, Jacobs School of Engineering, University of California San DiegoDepartment of Cellular and Molecular Medicine, School of Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, School of Medicine, University of California San DiegoFaculty of Biology, Division of Evolutionary Biology, Ludwig-Maximilian University of MunichDepartment of Medicine, School of Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, School of Medicine, University of California San DiegoTranscription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.https://doi.org/10.1038/s41467-018-08236-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gregory J. Fonseca Jenhan Tao Emma M. Westin Sascha H. Duttke Nathanael J. Spann Tobias Strid Zeyang Shen Joshua D. Stender Mashito Sakai Verena M. Link Christopher Benner Christopher K. Glass
spellingShingle	Gregory J. Fonseca Jenhan Tao Emma M. Westin Sascha H. Duttke Nathanael J. Spann Tobias Strid Zeyang Shen Joshua D. Stender Mashito Sakai Verena M. Link Christopher Benner Christopher K. Glass Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages Nature Communications
author_facet	Gregory J. Fonseca Jenhan Tao Emma M. Westin Sascha H. Duttke Nathanael J. Spann Tobias Strid Zeyang Shen Joshua D. Stender Mashito Sakai Verena M. Link Christopher Benner Christopher K. Glass
author_sort	Gregory J. Fonseca
title	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_short	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_full	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_fullStr	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_full_unstemmed	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_sort	diverse motif ensembles specify non-redundant dna binding activities of ap-1 family members in macrophages
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.
url	https://doi.org/10.1038/s41467-018-08236-0
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Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

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