АТP AS THE MARKER OF POWER EXCHANGE CONDITION AT THE EXPERIMENTAL ISCHEMIA OF THE MYOCARDIUM DUE TO METABOLIC DRUGS INTRODUCTION

• Main Authors: Vladimir Kukes, Tatyana Gorbach, Olesya Romashchenko, Vadim Rumbesht
• Format: Article
• Language: English
• Published: Pensoft Publishers 2016-09-01
• Series: Research Results in Pharmacology
• Subjects: ATP; myocardial metabolism; cardiocytoprotection
• Online Access: https://rrpharmacology.pensoft.net/article/31085/download/pdf/

For the purpose of definition of an adequate marker of a power exchange condition at the experimental ischemia of the myocardium due introduction of metabolic drugs, the experimental research on 60 rats-males of Wistar line has been spent. At experimental myocardial ischemia it has been found out energy-saving effects of trimetazidine, cytoflavin, meldonium, phosphocreatine, which were reached by different ways and in different degree. The indicator of ATP concentration in blood or erythrocytes closely correlated with the level of ATP in myocardial homogenates and with activity of mitochondrial heart enzymes – succinate dehydrogenase, citrate synthase, pyruvate dehydrogenase. Thus, this indicator can be recommended to study to assess the effectiveness of cardiocytoprotectors as the most appropriate marker of their energy-saving effect.