Serum concentrations of nitrite and malondialdehyde as markers of oxidative stress in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Serum concentrations of nitrite and malondialdehyde as markers of oxidative stress in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

BACKGROUND: Chronic myeloid leukemia is a neoplasm characterized by clonal expansion of hematopoietic progenitor cells resulting from the (9:22)(q34,11) translocation. The tyrosine kinase abl fusion protein,the initial leukemogenic event in chronic myeloid leukemia, is constitutively activated thus...

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Bibliographic Details
Main Authors: Maria Juracy Petrola, Alana Joselina Montenegro de Castro, Maria Helena da Silva Pitombeira, Maritza Cavalcante Barbosa, Acy Telles de Souza Quixadá, Fernando Barroso Duarte, Romelia Pinheiro Gonçalves
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
Leukemia
myelogenous
chronic
BCR-ABL positive
Oxidative stress
Protein-tyrosine kinases
Malondialdehyde
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000500011

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000500011

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