The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis

The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis

Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood. Here we show that the mammalian Rho GEF homolog, ECT-2, functions through the conserved RAS/ERK M...

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Bibliographic Details
Main Authors: Saravanapriah Nadarajan, Firaz Mohideen, Yonatan B Tzur, Nuria Ferrandiz, Oliver Crawley, Alex Montoya, Peter Faull, Ambrosius P Snijders, Pedro R Cutillas, Ashwini Jambhekar, Michael D Blower, Enrique Martinez-Perez, J Wade Harper, Monica P Colaiacovo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
MAP kinase
SYP-2
germline
crossover recombination
synaptonemal complex
meiosis
Online Access:https://elifesciences.org/articles/12039

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